Let me expand on my comment. First of all, the Metris is a Vito is a V-class, structurally and safety system-wise.
Structurally, the Metris is a unitary monocoque, with Saint Gobains Sekurit* safety glass (it cubes when it breaks, making it blunt and much less likely to slice you up). The structure has channeling members* to divert the energy around the high-strength steel passenger safety cage*, as well as deformable sections* to absorb as much energy as it can. So the cars structure is about as safe as a car can be.
The van has front*, front side*, and side curtain airbags. It has pyrotechnic pretensioners* in the front seatbelts. In the event of a crash, the car will so detect it, unlock all the doors*, and enable the electric hazard lights*, so as to lesson the likelyhood that someone that was trailing you will hit you. Finally, the car is equipped with the superior IsoFIX child seat safety anchor system, vastly superior to American standard LATCH systems, to best fix a child seat into the interior.
You have the ESP*. ESP is many things. It provides ASR (a Volvo first innovation, by the by) traction control to improve acceleration in slippery conditions. It also gives Stability Control*, which will under practically any circumstances prevent you from losing control of the vehicle (Note: Not all stability control systems are created equal, and MBs current system is generally considered the best). It has, of course, ABS* with four-channel control* (if any one brake line fails, you still have the other three wheels), as well as an entirely separate mechanical drum-type parking brake on the rear wheels*.
Of course, while Mercedes generally does this stuff better than other manufacturers, all cars have that stuff now- its legally mandated. Here's what isn't, but is standard on the Metris. EBD*- Electronic Brakeforce Distribution*- the car will vary the brake force individually at each wheel to maintain stability in a stop. Brake-Assist*- If the car detects that you are letting off the brake too early, or not providing enough force for your panicked attempt, it will deploy maximum brake force on your behalf. Brake-Prefill*- If you let off the gas in a panicked manner, the car will pre-fill the brake system and apply the brakes gently to the pads, saving precious milliseconds, applying the full force of them immediately upon you touching the pedal. Brake Disc Wipe*, which will gently touch the pads to the brakes when they get wet, keeping them dry and ready to provide full force braking when you need it.
Then you have some other cool stuff. First of all, the ESP is Load Adaptive*. That means that it calculates your center of gravity and applies ESP according to your vehicles current loading. Thus, if you have a load of 7 people, it will take that into account. Next, you have Crosswind Assist*, which will detect severe cross-winds and use the brakes to pull you back on course, instead of blowing you into the car next to you. Next, the electric power steering has a degree of self-steer on it, so it keeps you on the straight and narrow against a variety of things- like more minor crosswinds. And last, but certainly not least, Attention Assist* will study your driving habbits, and alert you if you are starting to demonstrate substantially reduced driving ability- and it does work, it usually comes on about 10 seconds after I start wondering if I need coffee.
Thats the standard stuff right there. If you choose to select the Active Safety Package or Active Safety Package W/ Active Park Assist, you will get a few more features. The first is Collision Prevention Assist*, which will monitor the space in front of your van, and if it detects potential for a collision it will simultaneously sound off a warning to you, while calculating the minimum braking force needed to avoid a crash- as soon as you hit the pedal, it will deploy that force. Which not only stops or substantially reduces the force with which you hit the car in front of you, but also reduces the potential for you being rear-ended by the person behind you. Then there is Lane Keep Assist*, which will vibrate the steering wheel if you get out of your lane without signaling. And there is Blind Spot Assist*, which lights up a little triangle in the sideview mirror, to tell you there is somebody in the (substantial) blind spot, and will beep at you if you signal while there is someone blocking you (a sidebar affect is that it reduces the space you mentally need to change lanes, so you can move through traffic a lot faster).
What are all these asterisks? The asterisks indicate a feature that Mercedes-Benz invented, or at the very least, brought to market first. Which is why I was so puzzled by your question. Of course its safe. Its a Mercedes-Benz. They invented automotive safety. Long before anybody cared about it, and at a time where Ford learned that advertising safety made people think your car was unsafe.
By the way, here is the V-class video link, which also shows off its ESP system:
https://youtu.be/wUPE8GRN4wo